DSpace Repository

In Vitro Antiplasmodial Activities of Crude Extracts ofCarissa edulis, Azadirachta indica, Cassia siamea andHarrisonia abyssinica against Plasmodium falciparum

Show simple item record

dc.contributor.author Oduor, P. L
dc.contributor.author Muleke, C. I.
dc.contributor.author Shivairo, S. R
dc.date.issued 2018-01
dc.date.accessioned 2021-04-22T09:02:39Z
dc.date.available 2021-04-22T09:02:39Z
dc.identifier.uri http://41.89.96.81:8080/xmlui/handle/123456789/2449
dc.description.abstract The emerging resistance of Plasmodium falciparum to chloroquineand sulfadoxine pyrimethamine drugs in Kenya has necessitated the need to look for new more effective antimalarial drugs. This study investigated the in vitro antiplasmodial activities of methanolic and aqueous crude extracts of Carissa edulis, Azadirachta indica, Cassia siamea and Harrisonia abyssinica on Plasmodium falciparum strains. Drug assays were conducted using SYBR Green 1 dye. Two Reference Plasmodium falciparum strains, 3D7 and W2 were assayed against two anti-malarial conventionaldrugs and crude extracts of Carissa edulis, Azadirachta indica, Cassia siamea and Harrisonia abyssinica to generate 50% inhibitory concentrations of chloroquine, mefloquine, methanolic and aqueous extracts. These extracts have potential for antimalarial activities thatcan be used to develop pure compounds for prospective antimalarial molecules for therapeutic uses. Methanolic and aqueous extracts of Carissa edulis, Azadirachta indica, Cassia siamea and Harrisonia abyssinica demonstrated in vitro antiplasmodial effect on the two Plasmodium falciparum strains. These findings support the hypothesis that these plants have antiplasmodial activities against Plasmodium falciparum strains through the active phytochemicals found in them. The extracts f en_US
dc.description.sponsorship Egerton University, Department of Biological Sciences en_US
dc.language.iso en en_US
dc.publisher Egerton University en_US
dc.subject In Vitro Antiplasmodial Activities en_US
dc.title In Vitro Antiplasmodial Activities of Crude Extracts ofCarissa edulis, Azadirachta indica, Cassia siamea andHarrisonia abyssinica against Plasmodium falciparum en_US
dc.type Other en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account