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Tissue Enzymes as Markers of Cardiac Damage during Trypanosoma brucei rhodesiense Infection of Sheep

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dc.contributor.author Mavura, Hawa
dc.contributor.author Ngure, Raphael
dc.contributor.author Maiyo, Zipporah
dc.contributor.author Murilla, Grace
dc.date.issued 2017
dc.date.accessioned 2021-07-07T08:47:26Z
dc.date.available 2021-07-07T08:47:26Z
dc.identifier.issn 2319-7064
dc.identifier.uri http://41.89.96.81:8080/xmlui/handle/123456789/2648
dc.description.abstract This study was done to determine markers of cardiac and CNS involvement during HAT using sheep where eight sheep were intravenously inoculated with 1 × 104 T. b. rhodesiense. Two were uninfected. Jugular blood vein samples were used for parasitological analyses and determination of serum concentrations of total protein, LDH and CK and their isoenzymes. There was an increase in total protein, total LDH and total CK activities in both serum and CSF. A flip over pattern LDH1:LDH2 ratio was observed. It was concluded that serum LDH1/LDH2 ratio, has a potential diagnostic value in determination of cardiac damage. en_US
dc.description.abstract This study was done to determine markers of cardiac and CNS involvement during HAT using sheep where eight sheep were intravenously inoculated with 1 × 104 T. b. rhodesiense. Two were uninfected. Jugular blood vein samples were used for parasitological analyses and determination of serum concentrations of total protein, LDH and CK and their isoenzymes. There was an increase in total protein, total LDH and total CK activities in both serum and CSF. A flip over pattern LDH1:LDH2 ratio was observed. It was concluded that serum LDH1/LDH2 ratio, has a potential diagnostic value in determination of cardiac damage. en_US
dc.language.iso en en_US
dc.publisher International Journal of Science and Research (IJSR) en_US
dc.subject Trypanosomiasis, LDH, CK, CSF, Serum en_US
dc.subject Trypanosomiasis, LDH, CK, CSF, Serum en_US
dc.title Tissue Enzymes as Markers of Cardiac Damage during Trypanosoma brucei rhodesiense Infection of Sheep en_US
dc.type Article en_US


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